A clinico-hematological study of sickle cell disease among adult patients in Makkah, Saudi Arabia.

Background: Sickle cell disease is an autosomal recessive characterized by aberrant production of hemoglobin S (HbS). The disease's presentation and severity varied substantially between people from various socioeconomic backgrounds geographical regions. clinical picture includes hemolytic anemia, vascular occlusion events, acute persistent pain, organ damage. Objective: To investigate the hematological characteristics adult sickle patients. Methodology: study was conducted utilizing outpatient inpatient data obtained retrospectively a specialist hospital in Makkah city January 2019 to December 2019. This collected all patients anemia (SCA) validated high performance liquid chromatography (HPLC) ages 18 50. gathered laboratory database contains demographic findings CBCs performed on fully automated hematology analyzer, as well HPLC results for percentages variant hemoglobins within group. comprised total 130 participants with anemia. All above patients' were documented archives. Results: mean age 30.5±11.1 years. Pearson correlation male showed significant positive correlations hemoglobin-S leucocytes (r= 0.503, P